Mariano Esperatti
Research Physician
marianoesperatti(ELIMINAR)@gmail.com
Mariano Esperatti is a specialist in internal medicine and intensive care through Universidad Nacional de La Plata (Argentina) and holds a Master’s in Comprehensive Care of Critical and Emergency Patients from the University of Barcelona. He is currently involved in the clinical research lines on Nosocomial Pneumonia and basic research in the animal model of Pneumonia Associated with Mechanical Ventilation.
His activity in the line of nosocomial pneumonia focuses on accurately determining treatment failure and its relationship with the systemic inflammatory response - a crucial matter when evaluating new therapeutic strategies for this disease. To this end, he evaluates different non-antibiotic treatment strategies aimed at improving clinical outcomes by attenuating the inflammatory response. In the animal model, his activity focuses on evaluating different strategies for preventing ventilator-associated pneumonia (VAP) and the diagnostic yield of different methods and their relationship with antibiotic therapy.
Together with Dr. Néstor Soler, he participates in the line of Exacerbations of Chronic Obstructive Pulmonary Disease (ECOPD), particularly studying the inflammatory response in ECOPD, the value of sputum characteristics and optimization of antibiotic treatment by using strategies that take these variables into account.
The preliminary results of this research suggest that antibiotic use in ECOPD could be reduced considerably. Optimizing knowledge of the inflammatory response and defining treatment failure in VAP will improve the evaluation of new therapeutic strategies.
Publications
Nosocomial pneumonia in the intensive care unit acquired by mechanically ventilated versus nonventilated patients
Esperatti M, Ferrer M, Theessen A, Liapikou A, Valencia M, Saucedo LM, Zavala E, Welte T, Torres A
Am J Respir Crit Care Med. 2010 Dec 15;182(12):1533-9.
Validation of the American Thoracic Society–Infectious Diseases Society of America Guidelines for Hospital-Acquired Pneumonia in the Intensive Care Unit.
Ferrer M, Liapikou A, Valencia M, Esperatti M, Theessen A, Martinez JA, Mensa J, Torres A.
Clin Infect Dis 2010; 50: 945–952.
Efficacy of linezolid compared to vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated pigs
Martinez-Olondris P, Rigol M, Soy D, Guerrero L, Agusti C, Quera MA, Li Bassi G, Esperatti M, Luque N, Liapikou M, Filella X, Marco F, de la Bellacasa JP, Torres A.
Crit Care Med. 2011 Sep 15.
The preliminary results of his research suggest that antibiotic use in exacerbations of chronic obstructive pulmonary disease could be reduced considerably