Investigació Aplicada en Malalties Respiratòries

The manuscript was published in the online version of European Respiratory Journal last July 20, 2011

Further studies may corroborate the different IL-6 responses among different populations who initiate weaning, and its potential clinical implications, but in the manuscript entitled: The effect of spontaneous breathing on systemic interleukin 6 during ventilator weaning, it is clear IL-6 increases during the Spontaneous breathing trial (SBT) and that this increase is more evident in COPD patients who fail the SBT.

Forty-nine SBTs of 30-minute duration were performed on different mechanically-ventilated patients, classified as SBT failure or success. Authors found that IL-6 levels increased from mechanical ventilation to spontaneous breathing in all patients (p=0.02) and in COPD population (p=0.05) with SBT failure compared to success, but not in non-COPD patients (p=0.12). Thus in conclusion, systemic IL-6 increases during a 30-minute failed SBT, especially in COPD patients. This is the first published study that assesses inflammatory response during ventilator weaning.