Montserrat Rigol
Senior Researcher
mrigol(ELIMINAR)@clinic.ub.es
Doctor from the Faculty of Veterinary Medicine of the Autonomous University of Barcelona. She is a researcher at the August Pi i Sunyer Institute of Biomedical Research (IDIBAPS) and leads or collaborates on research projects in the field of experimental respiratory medicine and cardiology.
As a member of Dr. Torres’ experimental laboratory, she takes part in research projects using a pig animal model to study the effect of different antibiotic treatments, such as linezolid and vancomycin, on ventilator-associated pneumonia (VAP).
In the field of experimental cardiology, she participates directly in a line of research in the filed of myocardial regeneration using mesenchymal stem cells in a pig model of acute myocardial infarction. This project has developed an infarction model in pigs that is reproducible and has similar clinical and anatomical and pathological characteristics to those of humans. Pig mesenchymal stem cells have also been cultivated in collaboration with the Cellular Physiology Laboratory of Hospital Sant Pau and different techniques are being standardized for marking these cells to administer them and study the effect of cellular therapy.
The results of this line of research lead to a clear benefit: when these cellular therapies can be applied to humans in clinical practice, they will contribute to mitigating cardiac remodeling and subsequent chronic heart failure in patients who have suffered acute myocardial infarction.
Publications
An experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated piglets
Martínez-Olondris P, Sibila O, Agustí C, Rigol M, Soy D, Esquinas C, Piñer R, Luque N, Guerrero L, Quera MÁ, Marco F, de la Bellacasa JP, Ramirez J, Torres A
Eur Respir J. 2010 Oct;36(4):901-6. Epub 2010 Mar 29.
Development and validation of a high performance liquid chromatography method to determine linezolid concentrations in pig pulmonary tissue
Guerrero L, Martínez-Olondris P, Rigol M, Esperatti M, Esquinas C, Luque N, Piñer R, Torres A, Soy D
Clin Chem Lab Med. 2010 Mar;48(3):391-8
Efficacy of linezolid compared to vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated pigs
Martinez-Olondris P, Rigol M, Soy D, Guerrero L, Agusti C, Quera MA, Li Bassi G, Esperatti M, Luque N, Liapikou M, Filella X, Marco F, de la Bellacasa JP, Torres A.
Crit Care Med. 2011 Sep 15.
Effects of Manual Rib Cage Compressions on Expiratory Flow and Mucus Clearance During Mechanical Ventilation.
Martí JD, Bassi GL, Rigol M, Saucedo L, Ranzani OT, Esperatti M, Luque N, Ferrer M, Vilaro J, Kolobow T, Torres A.
Crit Care Med. 2013 Jan 10.
Linezolid limits burden of methicillin-resistant Staphylococcus aureus in biofilm of tracheal tubes.
Fernández-Barat L, Ferrer M, Sierra JM, Soy D, Guerrero L, Vila J, Li Bassi G, Cortadellas N, Martínez-Olondris P, Rigol M, Esperatti M, Luque N, Saucedo LM, Agustí C, Torres A.
Crit Care Med. 2012 Aug;40(8):2385-9.
Direct analysis of bacterial viability in endotracheal tube biofilm from a pig model of methicillin-resistant Staphylococcus aureus pneumonia following antimicrobial therapy.
Fernández-Barat L, Li Bassi G, Ferrer M, Bosch A, Calvo M, Vila J, Gabarrús A, Martínez-Olondris P, Rigol M, Esperatti M, Luque N, Torres A.
FEMS Immunol Med Microbiol. 2012 Jul;65(2):309-17
Effects of duty cycle and positive end-expiratory pressure on mucus clearance during mechanical ventilation*.
Li Bassi G, Saucedo L, Marti JD, Rigol M, Esperatti M, Luque N, Ferrer M, Gabarrus A, Fernandez L, Kolobow T, Torres A.
Crit Care Med. 2012 Mar;40(3):895-902.
She takes part in research projects on a pig animal model to study the effect of different antibiotic treatments and myocardial regeneration using mesenchymal stem cells