Investigació Aplicada en Malalties Respiratòries

Research Lines

Animal Model

Objectives
  • To provide a “pure” animal model of pneumonia associated with mechanical ventilation due to Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus
  • To study the efficacy of new antibiotics and their pharmacokinetic/pharmacodynamic (PK/PD) relationships to the aforementioned microorganisms
  • To study nonantibiotic therapies in pneumonia
  • To study ventilator associated pneumonia (VAP)
Projects in Progress
  • Linezolid versus vancomycin in pneumonia due to multiresistant Staphylococcus aureus (MRSA)
  • Study of biofilm in endotracheal tubes
  • Study of different techniques for obtaining samples for microbiologic diagnosis of VAP
Milestones Achieved
  • Model validation
  • Efficacy of intravenous corticosteroids for VAP due to Pseudomonas aeruginosa
Future Challenges
  • Consolidation of the animal model as a reference standard for studies of VAP
    • Demonstration of the use of new antibiotics and new forms of administration
    • Study of new systems for preventing community-acquired pneumonia (CAP)
    • Study of new systems for airway management

Publications

  • Effects of glucocorticoids in ventilated piglets with severe pneumonia

    Sibila O, Luna C, Agustí C, Baquero S, Gando S, Rizzo Patrón J, García Morato J, Absi R, Famiglietti A, Vay Carlos A., Von Stecher F, Torres A

    Eur Respir J 2008; 32: 1–10

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  • Experimental severe Pseudomonas aeruginosa Pneumonia and Antibiotic Therapy in piglets receiving Mechanical Ventilation

    Luna C, Baquero S, Gando S, Risso J, García J, Sibila O, Absi R, Famiglietti A, Vay C, Von Stecher F, Goffredo D, Bruno D, Agustí C, Torres A.

    Chest, August 2007, 132 (2): 523-531.

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  • Experimental Pseudomonas aeruginosa pneumonia: evaluation of the associated inflammatory response

    Sibila O, Agustí C, Torres A, Baquero S, Gando S, Patrón JR, Morató JG, Goffredo DH, Bassi N, Luna CM

    Eur Respir J 2007; 30 (6): 1167-1172

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  • Hemosiderin deposits confounds tracking of iron-oxide labelled stem cells

    Rigol M, Solanes N, Roqué M, Farré J, Batlle M, Roura S, Bellera N, Prat-Vidal C, Sionis A, Ramírez J, Sitges M, Sanz G, Bayés-Genís A, Heras M.

    Transpl Proc 2008; 40: 3619-3622.

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  • Effects of Cyclosporine, Tacrolimus and Sirolimus on Vascular Changes related to immune response: an Experimental Study

    Rigol M, Solanes N, Sionis A, Gálvez C, Martorell J, Rojo I, Brunet M, Ramírez J, Roqué M, E, Roig E, Pérez-Villa F, Barquín L, Pomar JL, Sanz G, Heras M.

    J Heart Lung Transplant 2008; 27(4): 416-22.

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