Investigació Aplicada en Malalties Respiratòries

Research Lines

Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)

  • To characterize infectious exacerbations of chronic obstructive pulmonary disease (COPD)
  • To identify biological markers of infection in COPD
  • To rationalize the use of antibiotics in exacerbations of COPD
Projects in Progress
  • Study of the value of procalcitonin (PCT) in exacerbations of COPD requiring hospitalization
  • Multicenter study of the prevalence of infections due to Aspergillus species in exacerbations of COPD
  • Multicenter study on optimizing the diagnosis of exacerbations in COPD: AUDIEPOC
  • Utility of Antibiotic Treatment in Exacerbations of COPD Without Sputum Purulence: a Randomized, Double-Blind Controlled Clinical Trial on Efficacy and Safety.
Milestones Achieved
  • It has been reported that bacterial infection causes 50% of exacerbations of COPD
  • Bacterial colonization in COPD correlates significantly with the cytokine-associated inflammatory response in bronchoalveolar lavage
  • Sputum purulence as an exacerbation criterion correlates with the existence of bacterial infection in exacerbations of COPD
Future Challenges
  • Identification of biological markers for rapid detection of infectious exacerbations of COPD in severe and outpatient cases
  • Study of the relevance of colonization of the airways by Aspergillus species in patients with severe COPD
  • Search for an effective strategy to rationalize the widespread use of antibiotics in COPD


  • Geographic differences in clinical characteristics and management of COPD: the EPOCA study

    Marc Miravitlles, Cristina Murio, Gema Tirado-Conde, Gur Levy, Hana Muellerova, Joan B Soriano, Alejandra Ramirez-Venegas, Fanny WS Ko, Byron Canelos-Estrella, Eduardo Giugno, Miguel Bergna, Ivan Chérrez, Antonio Anzueto.

    International Journal of COPD. 2008:3(4) 1–12.

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  • Prevalence of COPD in Spain: Impact of undiagnosed COPD on quality of life and daily life activities.

    Miravitlles M, Soriano JB, García-Río F, Muñoz L, Duran-Taulería E, Sánchez G, Sobradillo V, Ancochea J

    Thorax 2009; 64: 863-868.

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  • COPD severity score as a predictor of failure in exacerbations of COPD. The ESFERA study.

    Miravitlles M, Izquierdo I, Herrejon A, Torres JV, Baró E, Borja J

    Respir Med 2011; 105: 740-747.

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  • Changes in management of chronic obstructive pulmonary disease (COPD) in primary care: EMMEPOC study

    Soler N, Ballester E, Martin A, Gobartt E, Miravitlles M, Torres A

    Respir Med. 2010 Jan;104(1):67-75.

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  • Chronic obstructive pulmonary disease and pneumonia

    Huerta A, Domingo R, Soler N

    Arch Bronconeumol. 2010;46 Suppl 3:28-31.

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