Investigació Aplicada en Malalties Respiratòries

Research Lines

Noninvasive Ventilation (NIV)

  • To study the efficacy of noninvasive ventilation (NIV) in weaning from invasive mechanical ventilation
  • To study the withdrawal of NIV in acute hypercapnic respiratory failure
  • To study the relationship between bacterial colonization of the airways and the efficacy of NIV
Projects in Progress
  • NIV in the prevention of post-extubation respiratory failure in patients with chronic respiratory diseases
  • Direct or gradual withdrawal of NIV in exacerbated hypercapnic respiratory failure
Milestones Achieved
  • NIV reduces the duration of tracheal intubation and improves mortality in patients with persistent failure of weaning
  • NIV reduces the need for intubation, and mortality in severe hypoxemic respiratory failure
  • NIV prevents post-extubation respiratory failure and improves survival in hypercapnic patients
  • Bacterial colonization by gram-negative bacilli is associated with therapeutic failure of NIV in patients with severe exacerbation of chronic obstructive pulmonary disease (COPD)
Future Challenges
  • More detailed study of new clinical indications for NIV
  • Implementation of strategies to improve the tolerance and clinical efficacy of NIV


  • Early non-invasive ventilation averts extubation failure in patients at risk. A randomized trial

    Ferrer M, Valencia M, Nicolas JM, Bernadich O, Badia JR, Torres A

    Am J Respir Crit Care Med 2006; 173: 164-170

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  • Non-invasive ventilation in severe hypoxemic respiratory failure. A randomized clinical trial

    Ferrer M, Esquinas A, Leon M, Gonzalez G, Alarcón A, Torres A

    Am J Respir Crit Care Med 2003;168:1438-1444

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  • Non-invasive ventilation after extubation in hypercapnic patients with chronic respiratory disorders: randomised controlled trial

    Ferrer M, Sellarés J, Valencia M, Carrillo A, Gonzalez G, Badia JR, Nicolas JM, Torres A

    Lancet. 2009 Sep 26;374(9695):1082-8

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  • The effect of spontaneous breathing on systemic interleukin-6 during ventilator weaning

    Sellares J, Loureiro H, Ferrer M, Amaro R, Farré R, Torres A

    Eur Respir J. 2011 Jul 20

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  • Noninvasive ventilation in acute hypercapnic respiratory failure caused by obesity hypoventilation syndrome and chronic obstructive pulmonary disease.    

    Carrillo A, Ferrer M, Gonzalez-Diaz G, Lopez-Martinez A, Llamas N, Alcazar M, Capilla L, Torres A.

    Am J Respir Crit Care Med. 2012 Dec 15;186(12):1279-85

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