Noninvasive Ventilation (NIV)
Objectives
- To study the efficacy of noninvasive ventilation (NIV) in weaning from invasive mechanical ventilation
- To study the withdrawal of NIV in acute hypercapnic respiratory failure
- To study the relationship between bacterial colonization of the airways and the efficacy of NIV
Projects in Progress
- NIV in the prevention of post-extubation respiratory failure in patients with chronic respiratory diseases
- Direct or gradual withdrawal of NIV in exacerbated hypercapnic respiratory failure
Milestones Achieved
- NIV reduces the duration of tracheal intubation and improves mortality in patients with persistent failure of weaning
- NIV reduces the need for intubation, and mortality in severe hypoxemic respiratory failure
- NIV prevents post-extubation respiratory failure and improves survival in hypercapnic patients
- Bacterial colonization by gram-negative bacilli is associated with therapeutic failure of NIV in patients with severe exacerbation of chronic obstructive pulmonary disease (COPD)
Future Challenges
- More detailed study of new clinical indications for NIV
- Implementation of strategies to improve the tolerance and clinical efficacy of NIV
Publications
Early non-invasive ventilation averts extubation failure in patients at risk. A randomized trial
Ferrer M, Valencia M, Nicolas JM, Bernadich O, Badia JR, Torres A
Am J Respir Crit Care Med 2006; 173: 164-170
Non-invasive ventilation in severe hypoxemic respiratory failure. A randomized clinical trial
Ferrer M, Esquinas A, Leon M, Gonzalez G, Alarcón A, Torres A
Am J Respir Crit Care Med 2003;168:1438-1444
Non-invasive ventilation after extubation in hypercapnic patients with chronic respiratory disorders: randomised controlled trial
Ferrer M, Sellarés J, Valencia M, Carrillo A, Gonzalez G, Badia JR, Nicolas JM, Torres A
Lancet. 2009 Sep 26;374(9695):1082-8
The effect of spontaneous breathing on systemic interleukin-6 during ventilator weaning
Sellares J, Loureiro H, Ferrer M, Amaro R, Farré R, Torres A
Eur Respir J. 2011 Jul 20
Noninvasive ventilation in acute hypercapnic respiratory failure caused by obesity hypoventilation syndrome and chronic obstructive pulmonary disease.
Carrillo A, Ferrer M, Gonzalez-Diaz G, Lopez-Martinez A, Llamas N, Alcazar M, Capilla L, Torres A.
Am J Respir Crit Care Med. 2012 Dec 15;186(12):1279-85
People working in this line
Lines list
- Animal Model
- Bronchiectasis non associated to Cystic Fibrosis (BQ-noFQ), Cystic Fibrosis (CF) and immune deficiencies
- Community-Acquired Pneumonia (CAP)
- Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
- Networks, European Projects and Collaborations
- Noninvasive Ventilation (NIV)
- Pulmonary complications in immunocompromised (IC) patients
- Translational research laboratory for advanced microbiology diagnosis and pathogen-host response in respiratory infections
- Ventilator-Associated Pneumonia (VAP)
