Investigació Aplicada en Malalties Respiratòries

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Gianluigi Li Bassi

Postdoctoral Researcher
glibassi(ELIMINAR)@clinic.ub.es

Publications at PubMed

Doctor from the University of Barcelona and graduated in Medicine from the University of Milan. He is a specialist in anesthesia and critical care. He takes part in the animal model line and his research focuses on finding new strategies to reduce the incidence of intubation-associated pneumonia.

In the lines of noninvasive ventilation (NIV) and ventilator-associated pneumonia (VAP), he aims to answer the following questions:

  • Leak-proof cuff with continuous aspiration of subglottic secretion: Is it feasible to prevent aspiration and translocation of bacteria from the oropharynx into the lower airways?
  • Enhancing clearance of airway secretions in intubated and mechanically ventilated patients: Could either ventilatory settings or an external mechanical device prevent retention of mucus following tracheal intubation?
  • Silver-coated endotracheal tubes: Is it possible to prolong the bactericidal effect of silver coated tubes?

His line of research focusses on devising and evaluating new devices and strategies to prevent intubation-associated pneumonia and translate the findings to ICU patients. In particular, he is interested in finding preventive approaches to maintaining physiologic airway sterility, following tracheal intubation.

His line of research could greatly reduce the incidence of intubation-associated pneumonia, which is still the second most common acquired infection in critically ill intubated and mechanically ventilated patients. Moreover, enhancing clearance of mucus could prevent pulmonary complications, such as the adverse effects of deep-tracheal suction; reduce the length of intubation time and reduce ICU mortality and morbidity.



Publications

  • Association between systemic corticosteroids and outcomes of intensive care unit-acquired pneumonia.  

    Ranzani OT, Ferrer M, Esperatti M, Giunta V, Bassi GL, Carvalho CR, Torres A.  

    Crit Care Med. 2012 Sep;40(9):2552-61.

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  • An In Vitro Study to Assess Determinant Features Associated With Fluid Sealing in the Design of Endotracheal Tube Cuffs and Exerted Tracheal Pressures*    

    Li Bassi G, Ranzani OT, Marti JD, Giunta V, Luque N, Isetta V, Ferrer M, Farre R, Pimentel GL, Torres A.

    Crit Care Med. 2013 Feb;41(2):518-526.

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  • Effects of Manual Rib Cage Compressions on Expiratory Flow and Mucus Clearance During Mechanical Ventilation.    

    Martí JD, Bassi GL, Rigol M, Saucedo L, Ranzani OT, Esperatti M, Luque N, Ferrer M, Vilaro J, Kolobow T, Torres A.

    Crit Care Med. 2013 Jan 10.

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  • Linezolid limits burden of methicillin-resistant Staphylococcus aureus in biofilm of tracheal tubes.  

    Fernández-Barat L, Ferrer M, Sierra JM, Soy D, Guerrero L, Vila J, Li Bassi G, Cortadellas N, Martínez-Olondris P, Rigol M, Esperatti M, Luque N, Saucedo LM, Agustí C, Torres A.  

    Crit Care Med. 2012 Aug;40(8):2385-9.

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  • Direct analysis of bacterial viability in endotracheal tube biofilm from a pig model of methicillin-resistant Staphylococcus aureus pneumonia following antimicrobial therapy.  

    Fernández-Barat L, Li Bassi G, Ferrer M, Bosch A, Calvo M, Vila J, Gabarrús A, Martínez-Olondris P, Rigol M, Esperatti M, Luque N, Torres A.  

    FEMS Immunol Med Microbiol. 2012 Jul;65(2):309-17

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  • Effects of duty cycle and positive end-expiratory pressure on mucus clearance during mechanical ventilation*.  

    Li Bassi G, Saucedo L, Marti JD, Rigol M, Esperatti M, Luque N, Ferrer M, Gabarrus A, Fernandez L, Kolobow T, Torres A.  

    Crit Care Med. 2012 Mar;40(3):895-902.

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