Investigació Aplicada en Malalties Respiratòries

Research team


Dolors Soy

Senior Researcher

Publications at PubMed

Doctor in Pharmacy from the Faculty of Pharmacy of the University of Barcelona. Specialist in Clinical Pharmacy, she works in the area of Clinical Pharmacokinetics, Population Pharmacokinetics and Pharmacokinetic/Pharmacodynamic (PK/PD) Modelling. Her main research topics are analysis of PK data using a population approach and modelling and study of PK/PD relationships in different groups of drugs, in both animal and human models.

Her research focuses on understanding the dose-concentration-effect relationship of drugs. The aim is to determine and quantify abnormal PK and PD parameters in specific populations and link them to clinical, biochemical or immunologic indicators that allow for subsequent optimization of treatments in clinical practice.

This line aims to answer questions such as what is the percentage of penetration in lung tissue for a specific drug in an animal model of pneumonia, what is the optimum antibiotic, dosage and route of administration for a clinical and microbiological cure of patients with ventilator-associated pneumonia, whether it is possible optimize dosage regimens based on PK/PD relationships in order to maintain or increase efficacy or reduce toxicity.

To carry out this type of studies, it is essential to implement gold-standard techniques for analytical determination of drugs in biological samples (HPLC) and pharmacokinetic-statistical computer programs that have been widely used and validated, such as NONMEM.

The results of her research activities may improve knowledge of the dose-effect relationship of drugs for the diseases and populations studied and contribute to the design of better dosage regimens (optimization of treatments). In the future, this could improve the quality of life of the patients.


  • An experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated piglets

    Martínez-Olondris P, Sibila O, Agustí C, Rigol M, Soy D, Esquinas C, Piñer R, Luque N, Guerrero L, Quera MÁ, Marco F, de la Bellacasa JP, Ramirez J, Torres A

    Eur Respir J. 2010 Oct;36(4):901-6. Epub 2010 Mar 29.

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  • Development and validation of a high performance liquid chromatography method to determine linezolid concentrations in pig pulmonary tissue

    Guerrero L, Martínez-Olondris P, Rigol M, Esperatti M, Esquinas C, Luque N, Piñer R, Torres A, Soy D

    Clin Chem Lab Med. 2010 Mar;48(3):391-8

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  • Efficacy of linezolid compared to vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated pigs

    Martinez-Olondris P, Rigol M, Soy D, Guerrero L, Agusti C, Quera MA, Li Bassi G, Esperatti M, Luque N, Liapikou M, Filella X, Marco F, de la Bellacasa JP, Torres A.

    Crit Care Med. 2011 Sep 15.

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  • Linezolid limits burden of methicillin-resistant Staphylococcus aureus in biofilm of tracheal tubes.  

    Fernández-Barat L, Ferrer M, Sierra JM, Soy D, Guerrero L, Vila J, Li Bassi G, Cortadellas N, Martínez-Olondris P, Rigol M, Esperatti M, Luque N, Saucedo LM, Agustí C, Torres A.  

    Crit Care Med. 2012 Aug;40(8):2385-9.

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Improving knowledge of the dose-effect relationship of drugs will help to design better dosage regimens

Involved in the following lines