-
Friday, 01/20/2023
Researchers from IAMR group publish in Nature Biotechnology a ‘Living medicine’ created to tackle drug-resistant lung infections.
This excellent result comes from a collaborative consortium in which our IDIBAPS-Ciberes group added an important translational value on this new promising technology developed by CRG, also with the collaboration of Institute of Agrobiotechnology (IdAB), a joint research institute of Spain’s CSIC and the government of Navarre. https://www.nature.com/articles/s41587-022-01584-9#citeas.
Researchers have designed the first ‘living medicine’ to treat lung infections. The treatment targets Pseudomonas aeruginosa, a type of bacteria which is naturally resistant to many types of antibiotics and is a common source of infections in hospitals.
The treatment involves using a modified version of the bacterium Mycoplasma pneumoniae, removing its ability to cause disease and repurposing it to attack P. aeruginosa instead. The modified bacterium is used in combination with low doses of antibiotics that would otherwise not work on their own.
Researchers tested the efficacy of the treatment in mice, finding that it significantly reduced lung infections. The ‘living medicine’ doubled mouse survival rate compared to not using any treatment. Administering a single, high dose of the treatment showed no signs of toxicity in the lungs. Once the treatment had finished its course, the innate immune system cleared the modified bacteria in a period of four days.
-
Wednesday, 01/18/2023
Anna Motos Galera read her doctoral thesis
Anna Motos Galera read her doctoral thesis
Anna Motos read her doctoral thesis on December 21st 2022 at the Faculty of Medicine of the University of Barcelona. Her thesis entitled: Novel antimicrobial agents and therapeutic approaches for nosocomial pneumonia caused by Pseudomonas aeruginosa has obtained the Cum Laude qualification.
Congratulations Anna!
-
Thursday, 11/17/2022
New doctoral thesis read!
Congratulations Rubén López
New doctoral thesis read!
Rubén López Aladid read his doctoral thesis on October 20th at the Faculty of Biology of the University of Barcelona. His thesis entitled: The role of the microbiota in patients with bronchiectasis not associated with cystic fibrosis has obtained the Cum Laude qualification.
Congratulations Rubén!
-
Thursday, 10/20/2022
Welcome to new fellow researchers!
New stays in the Research Group
Mariana Bichuette Cartuliares
Respiratory physiotherapist, MSc. in health science, and Ph.D. student in emergency medicine.
From Denmark, staying here from the 1st to the 21st of October 2022.
During her study stay, she is learning about diagnostics methods including animal research and FilmArray. In addition, She is learning and assisting in the microbiological culture of lower respiratory specimens and biopsies.
-
Thursday, 10/20/2022
Welcome to new fellow researchers!
Francisco José Molina Saladriga
PhD student, MSc. Specialist in critical care medicine.
From Medellin, Colombia. Staying from October 11 to November 24, 2022
He is learning from molecular biology techniques: FilmArray and microbiome in pneumonia.
-
Wednesday, 09/28/2022
The big participation of our researchers in the European Respiratory Congress, Barcelona 2022
The big participation of our researchers in the European Respiratory Congress, Barcelona 2022
Here is the list of Abstracts presented by our researchers in the European Respiratory Congress held in Barcelona 2022:
Relationship between the microbiome and the GOLD Stage during exacerbations. Laia Fernandez Barat (Barcelona, Spain), Ruben Lopez-Aladid, Leticia Bueno-Freire, Adrian Ceccato, Arturo Huerta, Nestor Soler, Antoni Torres
Association of sleep quality-quantity with sedentary time and physical activity in bronchiectasis Victoria Alcaraz Serrano (Barcelona, Spain), Beatriz Herrero-Cortina, Ane Arbillaga-Etxarri, Rodrigo Torres-Castro, Joan Daniel Martí-Romeu, Laia Fernández-Barat, Antoni Torres-Martí, Elena Gimeno-Santos
Risk factors for mortality in COPD patients with COVID-19 admitted to Intensive Care Unit. Laia Fernandez Barat (Barcelona, Spain), Sergio Alvarez-Napagao, Marta Barroso, Ana Motos, Albert Gabarrús, Adrian Ceccato, Raquel Pérez, Dario García, Denise Battaglini, Andrea Palomeque, Jesús Bermejo, Ferran Barbé, Antoni Torres
One year overview of follow-up in a post-covid consultation of critical patients with covid-19. Jessica Gonzalez Gutierrez (Lleida, Spain), Maria Zuil, Iván D. Benítez, Maria Aguilà, Sally Santisteve, Fatty Seck, Anna Moncusí-Moix, Clara Gort-Paniello, Antoni Torres, Ferran Barbé
Prognostic implications of comorbidity patterns in critically ill COVID-19 patients. Jordi De Batlle Garcia (Lleida, Spain), Iván D Benítez, Gerard Torres, Jessica González, David De Gonzalo-Calvo, Adriano D S Targa, Antoni Torres, Ferran Barbé
COVID-19 in Ventilated Elderly Patients: Data from 52 Intensive Care Units in Spain. Catia Cilloniz Campos (Barcelona, Spain), Anna Motos, Albert Gabarrus, Juan Manuel Pericas, Laia Fernandez, Tatiana Guadalupe Castañeda, Andrea Palomeque, Adrian Cecato, Antoni Torres
Identification of highly immunogenic epitopes in the SARS-CoV-2 Spike protein to produce monoclonal antibodies. Laia Fernandez Barat (Barcelona, Spain), Rubén López-Aladid, Leticia Bueno, Roc Farriol, Eduard Porta, Àlex López-Gavin, Ana Motos, Ruth Aguilar, Marta Vidal, Alfons Jiménez, Roberto Cabrera, Nil Vázquez, Enric Barbeta, Miquel Ferrer, Andrea Catalina Palomeque, Gemma Moncunill, Miquel Lozano, Alberto Garcia-Basteiro, Carlota Dobaño, Antoni Torres
Proteomic determinants of disease, mortality and sequelae in COVID-19 patients requiring invasive mechanicalventilation. Marta Molinero García (Lleida, Spain), Silvia Gómez, Ivan D Benítez, Jj Vengoechea, Jessica González, Clara Gort-Paniello, Anna Moncusí-Moix, María C García-Hidalgo, Manel Pérez-Pons, Gerard Torres, Jesús Caballero, Carme Barberà, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario García-Gasulla, Rosario Menéndez, Ana Motos, Óscar Peñuelas, Jordi Riera, Jesús F Bermejo-Martín, Antoni Torres, Ferran Barbé, David De Gonzalo-Calvo, D. Chalmers
Association between the viscoelastic characteristics and sputum colour in patients with bronchiectasis. Leticia Bueno Freire (Barcelona, Spain), Leticia Bueno-Freire , Nona Rovira, Victoria Alcaraz-Serrano, Héctor Sanz-Fraile, Nil Vàzquez-Burgos, Rosanel Amaro-Rodríguez, Patricia Oscanoa, Ruben López-Aladid, Andrea Palomeque, Ramon Farré, Jorge Otero, Laia Fernández-Barat *, Antoni Torres*
PSP kinetics in the prediction of VAP diagnosis. Adrian Ceccato (Ituzaingo (Prov. De Buenos Aires), Argentina), Marta Camprubi, Lieuwe Bos, Pedro Povoa, Ignacio Martin-Loeches, Aina Areny, Elena Campaña, Luis Morales, Paula Ramirez, Mariano Esperatti, Antoni Torres, Antonio Artigas
Towards a better diagnostic and treatment of ventilator-associated respiratory infections. Andrea Palomeque Flores (BARCELONA, Spain), Rubén López, Alba Soler, Leticia Bueno, Nona Rovira, Enric Barbeta, Ana Motos, Miriam Villanueva, Nil Vázques, Roberto Cabrera, Antonio Torres*, Laia Fernández-Barat*
Major candidate variables to guide personalized treatment with corticosteroids in critically ill patients with COVID-19: CIBERESUCICOVID study. Ana Motos Galera (Barcelona, Spain), Catia Cillóniz, Adrian Ceccato, Laia Fernández-Barat, Antoni Torres
Exacerbation risk factors in bronchiectasis colonized by Pseudomonas aeruginosa. Leticia Bueno Freire (Barcelona, Spain), Victoria Alcaraz Serrano, Nil Vázquez Burgos, Andrea Palomeque Flores, Patricia Oscanoa Huamán, Roberto Cabrera Ortega, Rubén López Aladid, Rosanel Amaro, Adrián Ceccato, Laia Fernández Barat*, Antoni Torres*
Validation of IDSA/ATS guidelines for ICU admission in very elderly patients with community-acquired pneumonia. Miquel Ferrer Monreal (Barcelona, Spain), Catia Cilloniz Campos, Juan Manuel Pericas, Leyre Serrano, Raul Mendez,Rosario Menendez, Luis Alberto Ruiz, Antoni Torres
ESTIMATING THE RISK OF BACTEREMIA IN HOSPITALIZED PATIENTS WITH PNEUMOCOCCAL PNEUMONIA. Leyre Serrano Fernandez (Bilbao (Bizkaia), Spain), Luis Alberto Ruiz Iturriaga, Silvia Perez Fernandez, Pedro Pablo España Yandiola, Catia Cilloniz, Beatriz Gonzalez Quero, Alejandro Rezola Carasusan, Ane Uranga , Antoni Torres Martí, Rafael Zalacain Jorge
Proteomic profiling of severe lung diffusion impairment in the recovery stage of COVID-19-induced ARDS. María C García-Hidalgo (Lleida, Spain), Jessica González, Iván D Benítez, Sally Santisteve, Fátima Rodríguez-Jara, Marta Molinero, Manel Pérez-Pons, Gerard Torres, Anna Moncusí-Moix, Clara Gort-Paniello, Paola Carmona, Jesús Caballero, Carme Barberà, Ana P. Tedim, Raquel Almansa, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario García-Casulla, Rosario Menéndez, Anna Motos, Óscar Peñuelas, Jordi Riera, Jesús F Bermejo-Martín, Antoni Torres, Ferrán Barbé, David De Gonzalo-Calvo
The efficacy of telavancin in comparison to linezolid on endotracheal tube biofilm in pigs with MRSA pneumonia. KASRA KIAROSTAMI (Barcelona, Spain), Denise Battaglini, Anna Motos, Leticia Bueno Freire, Alba Soler Comas, Hua Yang, Minlan Yang, Francesco Pagliara, Eli Aguilera Xiol, Andrea Meli, Joaquim Bobi, Tarek Senussi Testa, FrancescoI done , Montserrat Rigol, Gianluigi Li Bassi, Laia Fernández-Barat, Antoni Torres
-
Thursday, 09/15/2022
Congratulations to our Research Nurse
Congratulations to our Research Nurse for his Zambon award in the ERS Congress
Leticia Bueno, the research nurse of the group obtained the Zambon Award for his poster entitled: Association between the viscoelastic characteristics and sputum color in patients with bronchiectasis and presented in the European Respiratory Society Congress to be held in Barcelona on the 4-6 September
-
Thursday, 01/20/2022
Researchers from the Hospital Clínic-IDIBAPS lead the CIBERSUCICOVID project, which is about to identify the risk factors and prognosis of the patients infected by COVID-19 ingressats to the ICUs since the pandemic is going to start in Spain
Researchers from the Hospital Clínic-IDIBAPS lead the CIBERSUCICOVID project, which is about to identify the risk factors and prognosis of the patients infected by COVID-19 ingressats to the ICUs since the pandemic is going to start in Spain
Dr. Antoni Torres is the coordinator of the CIBERESUCICOVID project: Risk factors and prognosis of patients infected by COVID-19 and follow-up to any of the patients who have entered the Spanish ICUs.
The project is developed by researchers of the CIBER of Respiratory Diseases (CIBERES) and coordinated from the Hospital Clínic-IDIBAPS lead by Dr Antoni Torres.
The project forms part of the investigations carried out through the COVID-19 Fund at the end of the year 2020 and managed by the ISCIII, and will receive a total financing of 1,750,000 euros. He has comptat, així mateix, with the support of the Spanish Society of Intensive Critical Medicine and Coronary Unit (SEMICYUC) and the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR), with the participation of the Barcelona Supercomputing Center (BSC).
The main results show that the mortality rate of the patients entered by COVID-19 to the Spanish ICUs will be 31%.
CIBERESUCICOVID started in February 2020 and ends on December 31, 2021, has had the participation of more than 5,700 patients, enrolled in 69 Spanish ICUs, and has analyzed 1,068 samples of blood for the studies of epigenetics and biomarkers. Among the conclusions, it is worth highlighting the death rate at any of the high hospital, since, according to the results, more than 1% of the patients who have been in intensive cures. In addition, the CIBERES researchers have also identified the acquisition of an intra-hospital (nosocomial) pneumonia during entry with a factor associated with the persistence of coronavirus symptoms after three months. “We have studied the effect of corticosteroids on in-hospital mortality, finding several phenotypes in which no benefit is observed depending on age, initial severity, inflammatory status, and the absence of lymphopenia. Our results, therefore, will help to define which serious patients should receive corticosteroids ”, explains Torres
-
Monday, 10/11/2021
A new article of SARS-CoV-2 is published in Journal of Internal Medicine.
A new article is published in Journal of Internal Medicine.
The article is entitled: Low anti‐SARS‐CoV‐2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID‐19 patients.
In this article we studied the impact of antiSARS-CoV-2 S antibodies levels on survival, viral RNA-load in plasma, and N-antigenaemia in 92 COVID-19 patients over ICU admission. The corresponding author is Dr Antoni Torres.
-
Tuesday, 09/28/2021
Original Research Article has been published recently on the Critical Care Journal
Original Research Article has been published recently on the Critical Care Journal
The article is entitled: The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients.
In this study comparing changes in parameters between day 1 and day 3 of mechanical ventilation in COVID-19 ARDS patients, a higher ventilatory ratio at day 1 and more importantly an increase in the ratio by day 3 were significant predictors of in-hospital mortality. The significance of this finding is not completely understood but might reflect vascular microthrombosis phenomena and/or alveolar edema, factors associated with increased physiologic dead space. The first co-authors are Antoni Torres and Anna Motos.
