Investigació Aplicada en Malalties Respiratòries

kasra Kiarostami wants to thanks to Prof. Antoni Torres, Dr. Laia Fernandez, Dr. Ana Motos and all collaborators in the Theravance project the recent article " The efficacy of telavancin in comparison with linezolid on endotracheal tube biofilm in pigs with methicillin-resistant Staphylococcus aureus pneumonia" was published in International Journal of Antimicrobial Agents journal. The first author is kasra Kiorastami.

In summary, this research compared the efficacy of telavancin and linezolid in addressing biofilms on endotracheal tubes (ETT) in a porcine model simulating methicillin-resistant Staphylococcus aureus (MRSA) ventilator-associated pneumonia (VAP). While MRSA loads on the ETT and cuff did not significantly differ among control, linezolid, and telavancin groups, a notable finding revealed telavancin's ability to reduce MRSA biofilm on the ETT. This suggests potential advantages for telavancin in clinical settings, especially for elective patients. Despite acknowledging the study's limitation of a small sample size, we argue that this model aligns with real-world VAP scenarios in critically ill patients, emphasizing the need for further investigation. The study highlights telavancin's potential significance in combating biofilms and improving treatment approaches for VAP."